ratch wrote:When you do regular opioids on a daily basis, there are peaks and lows in your high. Not always detectable but present. And if you sleep longer than 4 hours a night while using opioids, chances are when you wake up you are reaching for your next dose to fight off the cusp of wd's. To fight the lack of opioids, the brain will fire aminos/proteins to try to get you to feel normal again....until your next dose. These changes gives the brain a small but noticeable point of reference on how you are supposed to feel without opioids, and that is what the slight uncomfortable feeling or slight onset of wd's is, the brain trying to regulate. This is all due to the 4 hr 1/2 life of all SAO's. Your brain still has a tiny pathway to normalcy again and will eventually find its way back to normal in a week or two for most people.
Now take a drug like buprenorphine (Sub) or methadone, these drugs have ridiculously long 1/2 lives, 34+ hours. So not only is the dose you just took saturating the brain for the next 34 hours, but so is the doses you took for the past week. Basically you are getting a "steady high" and the brain has no way to create a point of reference on how you are supposed to feel without opioids. (almost never slight wd's, mental stuff perhaps, but actual wd's almost never) Not only does the brain lose its way back to normalcy so to speak, but the search for normalcy, the brain firing of signals to feel good again is almost non existent... no reason with drugs that are by design made to keep you high "all the time".. So not only does the brain have no point of reference as to what "normal" without opioids feels like, but sparking up the endocrine gland/pituitary to produce the signals/proteins needed to feel good again is fucking rusty with sub or methadone...with SAO's it fires everyday!!!
So when you do a treatment like UROD or Naltrexone for sub, the drug is stripped/blocked from your brain and you are no longer dependent. But your brain is still lost. You may have snuck past the initial wd's which are not only mild at best due to the agonizingly long time it takes sub to leave your body, but you will not only get hit with PAWS which are the brains search for normalcy again, but you just passed the initial mapping phase which IS the wd's that you just avoided with UROD or naltrexone to begin with.
For SAO's I dont see any issues except for the extreme danger and loss of life that UROD procedures have. You are getting a shortcut!
But with sub, you are making things much harder in the long run, because sub wd's arent the rough part. The rough part is how fucking long it takes your brain to find its way back to normal again and with UROD/Naltrexone you just passed step one.
suboxalypsenow wrote:I would think slowly reducing to the point of feeling some withdrawal, stabilizing, and then reducing again is the gentlest way to get your brain to re-regulate as close to opioid naive as possible.
How does the brain 'stabilise' in this fashion? Say I drop from say 4 mg to 3 mg -- on day 1 after dropping, would my brain be behaving in any different way than on day 10? Or is it just a matter of "getting used" to life at 3mg?
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