I have a very pronounced histamine reaction to lower dose bupe. It took me awhile to recognize it and I didn't realize what it was until a friend suggested histamine. Then I remembered having the same thing often on SAOs. It has been well over a decade since I've had a SAO, so I had forgotten about that feeling. It gets more pronounced the lower I go.
My theory is that it is norbupe causing my histamine reaction.
I read that, once under the ceiling level doses, you have open available receptors after dosing with low dose bupe, so there are open receptors for the full agonist norbupe. Usually, at ceiling level doses, by the time norbupe is metabolized, bupe is already in the receptors and holding tight, and there is no place for norbupe to go. For me, geting well under 1mg brought on the SAO histamine itchies and other SAO feelings. perhaps this isn't the case for everybody, but I've always had an extremely sensitive reaction to opiates. Even after doing H for long enough to develop a tolerance, I didn't ever really seem to have much of one. I could get by on very small amounts. Maybe for people like me with sensitivity to opioids, norbupe is a bigger player than originally thought.
I am sure there is something horribly wrong in that theory, but it made sense to me last time I was trying to figure out the histamine issue.
All you have is your fire
And the place you need to reach
Don't you ever tame your demons
But always keep them on a leash
Telling subs to fuck off since March 20, 2017